| First Author | Derry JM | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 988 (Abstr.) | Mgi Jnum | J:12526 |
| Mgi Id | MGI:60771 | Citation | Derry JM, et al. (1989) Localization of the androgen receptor gene in the mouse X Chromosome and its relationship to X-linked zinc finger protein. Cytogenet Cell Genet 51:988 (Abstr.) |
| abstractText | Full text of Abstract: Localization of the Androgen receptor gene on the mouse X chromosome and its relationship to X-linked zinc finger protein. (A2362). JMJ Derry, AS Ryder-Cook, DB Lubahn, FS French, EM Wilson, DC Page, PJ Barnard. MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, CB2 2QH, England. The human androgen receptor is essential for expression of the normal male phenotype and defects in its function have led to a series of inherited disorders known as the androgen-insensitivity syndromes. We have mapped the androgen receptor gene (Ar), in 68 recombinant animals from an interspecific mouse backcross containing the mdx mutation, by pedigree breakpoint analysis, in relation to seven other known genetic markers. Our data find the Ar locus maps telomeric to mdx and the X-linked zinc finger protein Zfx and centromeric to Pgk-1, in a conserved segment homologous to the proximal long arm of the human X chromosome. Further, they show that Ar and Zfx are closely linked in the mouse. Zfx is a candidate gene for testis-determining factor, localized to the distal short arm of the human X chromosome. Our data suggest, therefore, that Ar and Zfx lie on either side of an evolutionary breakpoint on the mammalian X chromosome. |
