| First Author | Lalley PA | Year | 1979 |
| Journal | Cytogenet Cell Genet | Volume | 25 |
| Pages | 178 (Abstr.) | Mgi Jnum | J:18110 |
| Mgi Id | MGI:66126 | Citation | Lalley PA, et al. (1979) Gene assignment of argininosuccinate lyase to mouse chromosome 5. Cytogenet Cell Genet 25:178 (Abstr.) |
| abstractText | Full text of Abstract: Abstracts of meeting presentations. Gene assignment of argininosuccinate 1yme mouse chromosome 5. P.A. LALLEY,1 S.L. NAYLOR,2 and T.B. SHOWS2. 1Oak Ridge National Laboratory, Oak Ridge, and 2Roswell Park Memorial Institute, Buffalo. The genes coding for phosphoglucomutase-2 (PGM2) and peptidase S (PEPS) have been assigned to the pter->q21 region of human chromosome 4, and the genes coding for Beta- glucuronidase (GUS) and malate dehydrogenase (mitochondrial) (MDH2) have been assigned to the pter->q21 region of 7. In the mouse the homologous forms of the genes are located on chromosome 5. Recently NAYLOR et al. (Proc. Natn. Acad. Sci. USA 75: 6159, 1978) assigned the gene coding for argininosuccinate lyase (ASL) to the pter->q21 region of human 7. These data suggested that in the mouse the gene coding for ASL may be located on 5. To test this hypothesis 21 mouse, Chinese hamster primary hybrid clones segregating mouse chromosomes were analysed for the expression of ASL. Segregation and cytogenetic data show that ASL segregated concordantly with PGM-1 (homologous to human PGM2), Pep-7 (homologous to human PEPS) and mouse 5. In the mouse the gene order established by Mendelian genetic techniques is: cen-3lcM-Pgml-36cM-Gus-11cM-Mor-1 Mouse Pgm-1 is homologous to human PGM1 and Mor-1 is homologous to human MDH2. The regional assignments of Pep-7 and Asl are not known. However, comparative mapping data would suggest that Pep-7 will map in the cen-Pgm-1 region of the chromosome, and Asl will map to the Gus-Mor-1 region of 5. These data suggest that a region within the proximal half of mouse chromosome 5 is homologous to a region within the pter->q21 fragment of human chromosome 4, and that a region within the distal half of mouse chromosome 5 is a homologous to a region within the pter->q21 fragment of human chromosome 7. |
