| First Author | Martin-Iverson MT | Year | 2004 |
| Journal | MGI Direct Data Submission | Mgi Jnum | J:88597 |
| Mgi Id | MGI:3036117 | Citation | Martin-Iverson MT, et al. (2004) A novel mouse Chr5 locus Diht controls dopamine-induced hypothermia. MGI Direct Data Submission |
| abstractText | Mice of the strain C3H.PRI-Flvr, carrying genetically determined resistance to flaviviruses, have been shown to exhibit a potentiated hypothermia response to apomorphine, a non-selective dopamine agonist, unlike a congenic flavivirus-susceptible C3H/HeJARC mice that exhibit much lower apomorphine-induced hypothermia. In the current study, the potentiated hypothermic response observed in flavivirus resistant mice was shown to be dose-dependent, with strain differences being the most prominent at a moderate dose of apomorphine (1 mg/kg). In addition, hypothermic responses to apomorphine were shown to be under developmental regulation; aging increased the potency of apomorphine-induced hypothermia and abrogated strain and sex differences observed in young mice. Linkage analysis of mouse strain-dependent co-inheritance between flavivirus resistance and the ability of potentiated hypothermic response to apomorphine was performed using two genetically unrelated flavivirus-susceptible and two highly congenic flavivirus-resistant mouse strains in parallel with C3H.PRI-Flvr and C3H/HeJARC reference strains. This study has revealed a clear segregation between flavivirus resistance conferred by the Flv locus, and dopamine-controlled hypothermia conferred by a novel locus, Diht. Parallel studies in F1 and F2 heterozygote mice showed that the ability to develop a potentiated hypothermic response (Dihthigh) is inherited as the Chr5-linked dominant trait. The novel locus, Diht, has been mapped proximal to the Flv locus on a distal part of mouse Chr5 between microsatellite markers D5Mit41 and D5Mit158. |
