| First Author | Lalley PA | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1028-29 (Abstr.) | Mgi Jnum | J:14964 |
| Mgi Id | MGI:63113 | Citation | Lalley PA, et al. (1989) Comparative gene map of mouse Chromosome 9 and human Chromosome 3. Cytogenet Cell Genet 51:1028-29 (Abstr.) |
| abstractText | Full text of Abstract: Comparative gene map of mouse chromosome 9 and human chromosome 3. (A2227) PA Lalley, S Kiousis, W Golembieski, DI Smith; Wayne State University, Detroit, MI. Human chromosome 3 contains syntenic groups which are conserved on mouse chromosome 9, 6 and 16. The distal half of mouse 9 is homologous to a large conserved region of human 3 extending from 3p21 to 3q25. This conserved group contains genes for aminoacylase and Beta-galactosidase on HSA3p and transferrin, lactotransferrin, ceruloplasmin and retinol binding protein 1 and 2 on HSA3q. Interestingly RAF1 assigned to 3p25 and ribophoren 1 assigned to 3q are both located on mouse chromosome 6, thus indicating that considerable rearrangement has occurred during the evolution of this chromosome. In order to define further the conserved regions of human chromosome 3 and mouse chromosomes we have used Chinese hamster x mouse somatic cell hybrids to determine the mouse chromosome location of two unique sequence probes derived from human chromosome specific library. These sequences (D3S92, D3S93) have been mapped to HSA3p21.1-p21.2 (Smith et al., American Journal Human Genetics, submitted). Southern analysis of DNA from 12 somatic cell hybrids digested with EcoRl and hybridized to the probes indicate that both sequences lie within the conserved region on the distal half of mouse chromosome 9, thus extending this large conserved region between man and mouse. In the mouse this region is approximately 24 cm. |
