| First Author | Seiki K | Year | 1997 |
| Journal | Med Sci Res | Volume | 25 |
| Issue | 11 | Pages | 771-774 |
| Mgi Jnum | J:44676 | Mgi Id | MGI:1100802 |
| Citation | Seiki K, et al. (1997) Effect of estrogen on mouse brain development in the perinatal period. Med Sci Res 25(11):771-774 |
| abstractText | We studied the effect of estrogen administration (20 mu g estriol (E-3/pregnant mouse, i.m., four times during the prenatal period) on offspring brain development at the perinatal stage using cell-specific markers. Estriol increased expression of the neuron-specific markers, neuron-specific enolase (NSE) and neurofilament (NF), with time until 14 days after birth. Expression of a neuroglial marker, glial fibral acidic protein (GFAP), was not affected. Estriol treatment enhanced NSE-staining intensity in the preoptic area (POA) and anterior medial basal hypothalamus (AMBH) including the suprachiasmatic and ventromedial nuclei and amygdala (AM). However, this hormone had no effect on NF or GFAP expression in most of the brain areas with the exception of a severe decrease in GFAP expression in the hippocampus (Hip.). These results indicate that estrogen treatment during prenatal life influences the development of the reproductive organisation of the fetal brain, i.e. The POA-AMBH-AM functional complex. |
