| First Author | Forejt J | Year | 1974 |
| Journal | Mouse News Lett | Volume | 51 |
| Pages | 29 | Mgi Jnum | J:13666 |
| Mgi Id | MGI:61848 | Citation | Forejt J, et al. (1974) Hybrid sterility genetic system - mapping of Hst between T and H-2. Mouse News Lett 51:29 |
| abstractText | Full text of MNL contribution: Hybrid sterility genetic system - mapping of Hst-1 between T and H-2. 24 wild males of Mus musculus gave only sterile sons (mean weight of paired testes below 85mg) when mated with C57BL/10 females. The same wild males sired fertile progeny with C3H females. The difference in fertility of the two types of hybrids could be attributed to two allelic forms of a single gene as suggested by the observed 1:1 ratio of sterile and fertile male offspring of wild males and (B10xC3H)F1 females. In our previous studies (Ivanyi et al., Folia Biol. 15: 401, 1969; lvanyi and Mickova, In Immunogenetics of H-2 system, p.104 Karger, 1971) the gene was located on chromosome 17 (LG IX) and we propose now to designate it Hst-1, Hybrid sterility-1. By means of three-point test, we have now mapped the Hst-1 between T and H-2 with RF : T4.5 +/- 2.20Hst-1 13.5 +/- 4.07H-2. The five inbred strains share Hst-1s (ensuring sterility) allele: C57BL/10ScSnPh, A/Ph, BALB/c, DBA/1 and AKR/J whereas the Hst-l (fertility ensuring) allele is found in: C3H/Di, CBA/J, P/J, I/St, F/St inbred strains. Complementation tests indicate no involvement of t-alleles sterility factor in Hybrid sterility phenomenon, G-band analysis of mitotic chromosomes of sterile hybrids does not reveal any apparent structural rearrangements. (Forejt, Ivanyi) |
