| First Author | Hameister H | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1010 (Abstr. 2606) | Mgi Jnum | J:4570 |
| Mgi Id | MGI:53056 | Citation | Hameister H, et al. (1989) Physical and genetic linkage map of murine Chromosome 15. Cytogenet Cell Genet 51:1010 (Abstr. 2606) |
| abstractText | Full text of Abstract: Physical and genetic linkage map of murine chromosome 15. (A2606) H Hameister1, S Adolph1, O. Deimling2, J Meyer1. 1Abteilung Klinische Genetik, Universitat Ulm, D-7900 Ulm, FRG; 2Pathologisches Institut, Universitat Freiburg, D-7800 Freiburg, FRG The murine chromosome 15 is engaged in specific chromosomal aberrations in various kinds of tumors. Several oncogenes and proviral integration sites have been mapped to chromosome 15. In an ongoing study we have localized by in situ hybridization: murine leukemia virus integration site 2, Mlvi-2, to 15A2-B1; alpha-globin pseudogene 3, Hba-3ps, to 15D2; avian myelocytomatosis oncogene homolog, Myc, to 15D2-D3, plasmacytoma variant translocation site, Pvt-1, to 15D2-3; thyroglobulin, Tgn, to 15D/E parvalbumin, Pva, to 15E; simian sarcoma viral oncogene homolog, Sis, to 15E; murine mammary tumor virus integration site I, lnt-1, to 15F1-3; glycerol-3-phosphate dehydrogenase, Gdc-1, to 15Fl-1. For further refinement of localization a genetic linkage study was performed in interspecies backcrosses involving Mus spretus. The following genetic order was obtained (cM in brackets): Mlvi-2-(18.9 +/- 6.5)- Hba-3ps-(6.3 +/- 2.3)-Myc, Pvt, Tgn-(8.9 +/- 2.7)-Ly-6-(15.7 +/- 5.1)-Hox-3. The following genes are conserved in common linkage groups in man: MYC, PVT1 and TG in 8q24; PVALB and PDGFB (formerly v-sis) together with ARSA and DIA1 on distal 22q13: INT1 and GBD1 (homolog with Gdc-1) together with PFKX, HOX3, and ELA1 on proximal 12cen-q14. |
