| First Author | Burmeister M | Year | 2005 |
| Journal | MGI Submission | Mgi Jnum | J:96058 |
| Mgi Id | MGI:3529220 | Citation | Burmeister M, et al. (2005) Genetic modifiers of the ocular retardation pehnotype. MGI Submission |
| abstractText | Ocular retardation is a recessive murine mutation whose phenotypic expression is greatly affected by genetic background effects. Mice of the inbred 129/SvJ background that are homozygous for the Chx10or-J mutation are blind and have a thin, poorly differentiated retina and no optic nerve. A backcross between 129/SvJ and Mus musculus castaneus (CASA/Rk) produced animals that were homozygous for the Chx10or-J mutation, yet showed a much milder phenotype. Such animals were crossed to each other and selected for mild phenotype. After 6 generations of selection, partial recovery of visual function was observed, including presence of an optic nerve and pupillary response (Bone-Larson et al., 2000). Here, we have performed a genome scan to identify the genetic loci effecting this phenotype modification. Our scan revealed two significant loci on chromosomes 6 and 14 where the CASA/Rk alleles are maintained selectively. Markers were developed near retinal candidate genes, but none of the linkage regions peak on a known candidate gene. |
