| First Author | Mortimer A | Year | 1978 |
| Journal | Mouse News Lett | Volume | 59 |
| Pages | 30 | Mgi Jnum | J:13778 |
| Mgi Id | MGI:61957 | Citation | Mortimer A, et al. (1978) Hdc - kidney histidine decarboxylase. Mouse News Lett 59:30 |
| abstractText | Full text of MNL contribution: 6. Kidney histidine decarboxylase (EC 4.1.1.22) is an interesting enzyme in being inducible by oestrogen and repressible by testosterone. In a survey of untreated inbred mice we find three phenotypes: high (e.g. C3H/He, DBA/2), medium (e.g. C57BL, SWR/J) and low (SM/J) activities in the ratio of about 25:5:1. The segregation analysis between C3H/HE and C57BL indicates that a single locus with additively acting alleles is responsible for the difference; we designate this locus Hdc (a allele C3H/HE, b allele C57BL). This locus is probably the structural locus for histidine decarboxylase as preliminary evidence indicates a difference in heat stability between the enzymes from the two strains. Brain histidine decarboxylase activity is not affected between these strains and inhibitor studies indicate that the brain enzyme is a dopa dacarboxylase (i.e. the generalised amino acid decarboxylase EC 4.1.1.28). A further segregation analysis between SM and C57BL is in progress as is a study of the response of various strains to hormone treatment (Mortimer and Bulfield). |
