| First Author | Peters J | Year | 1980 |
| Journal | Mouse News Lett | Volume | 63 |
| Pages | 15-6 | Mgi Jnum | J:13856 |
| Mgi Id | MGI:62035 | Citation | Peters J, et al. (1980) Hexokinase. Mouse News Lett 63:15-6 |
| abstractText | Full text of MNL contribution: Biochemical variants: a) Hexokinase. A genetically determined electrophoretic variant of hexokinase-1 has been found in some mice of the Peru/Coppock stock. This variant has less anodal electrophoretic mobility than hexokinase-1 from all other inbred strains and stocks tested. Genetic analyses indicate that the variant is determined by an autosomal codominant gene. We propose that the common allele is designated Hk-la and the variant allele found in Peru/Coppock mice Hk-1b. The electrophoretic mobility of hexokinase-1 appears to be modified in testis where it has a faster anodal mobility than in kidney extracts. In addition a sperm specific hexokinase is also found. These effects are only found in testes where spermatogenesis is unimpaired since in males heterozygous for T(1;7)40H and T(11;19)42H which do not form spermatoza (Searle, A.G. et al., 1978. Ann. Biol. Anim. Bioch. Biophys. 18: 391) and in males under six weeks of age the electrophoretic mobility of hexokinase-1 is unmodified in testis and sperm specific hexokinase is not found. In heterozygotes for T(5;12)31H where reduced numbers of spermatozoa are found there is reduced activity of sperm specific hexokinase and both the modified and unmodified forms of hexokinase-1 occur in testis. (Peters and Andrews) |
