| First Author | Andrews SA | Year | 1979 |
| Journal | Mouse News Lett | Volume | 61 |
| Pages | 40 | Mgi Jnum | J:13814 |
| Mgi Id | MGI:61993 | Citation | Andrews SA, et al. (1979) Igh-1 and Pre-1 distal on Chromosome 12. Mouse News Lett 61:40 |
| abstractText | Full text of MNL contribution: T(5;12)31H (MNL 53: 30, 54: 38 and Beechey and Kirk, present issue) has been tested for linkage with Igh-1 and Pre-1, known to be about 11 units apart (Taylor et al., Nature 256: 644, 1975) but otherwise unlocated. Igh-1<b> Pre-1<b> T31H/Igh-1<a> Pre-1<a> + females were crossed to strain C3H/HeH males homozygous for Igh-1<a> and Pre-1<c>. Only one recombinant (Igh-1<b> Pre-1<a>/Igh-1<a> Pre-1<c> with normal karyotype) was found among 89 progeny typed for Igh-1 and 59 for Pre-1 alleles (females were not scored for the latter. Since location of these genes on Chr 5 seems to be ruled out by results of other linkage tests, e.g. with Pgm-1 (Taylor et al., loc. cit.) the results show that these loci are close to the T31H breakpoint at 12F1. Since all monosomic Ms(5<12>)31H progeny tested (6 for Igh-1 and 4 for Pre-1) carried the Igh-1<b> and Pre-1<b> alleles derived from the maternal translocated chromosome, it is clear that these genes must be in the 12<5> segment and thus proximal to the break-point. The most probable order of loci is Centromere.Igh-1.Pre-1.T31H, since the single recombinant would then be the result of a single rather than a double crossover. There is marked crossover suppression in the region of T31H. (Andrews, Beechey, Peters and Searle, with J. Johnson and T. Meo, Institut fur Immunologie der Universitat Munchen). |
