| First Author | Sparkes RS | Year | 1987 |
| Journal | Cytogenet Cell Genet | Volume | 46 |
| Pages | 696 (Abstr.) | Mgi Jnum | J:12315 |
| Mgi Id | MGI:60563 | Citation | Sparkes RS, et al. (1987) Mapping of genes encoding the subunits of guanine nucleotide-binding proteins (G-proteins) in the mouse. Cytogenet Cell Genet 46:696 (Abstr.) |
| abstractText | Full text of Abstract: Abstracts of workshop presentations. Mapping of genes encoding the subunits of guanine nucleotide-binding proteins (G-proteins) in the mouse. Sparkes RS,1 Cohn VH,2 Cire-Eversole P,2 Blatt C,2,3 Amatruda TT,2 Weiner LP,4 Nesbitt M,5 Reed RR,6 Lochrie MA,2 Fournier REK,7 Simon ML2. 1Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA. 2Department of Biology, Caltech, Pasadena, CA. 3Weizmann Institute, Rehovot, Israel. 4Department of Neurology, USC School of Medicine, Los Angeles, CA. 5Department of Biology, UCSD, LaJolla, CA. 6Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD. 7Department of Microbiology, USC School of Medicine, Los Angeles, CA. G-proteins are composed of 3 subunits (alpha, Beta and gamma) and mediate intracellular responses to a wide variety of extracellular stimuli. Using cDNA probes in the study of recombinant inbred strains of mice and rat/mouse or hamster/mouse somatic cell hybrids, the following assignments to mouse chromosomes have been made Gtalpha1 to 9; Gtalpha2 to 17; Gialpha2(18) to 9; and GBeta1 to 19. Of interest, is the generally wide dispersion of these related proteins. New nomenclature Gtalpha1 = Gtalpha2 = GNAT2 ; Gialpha2 = GNA12; GBeta1 = GNB1. |
