| First Author | Cox DR | Year | 1984 |
| Journal | Cytogenet Cell Genet | Volume | 37 (1-4) |
| Pages | 443-444 (Abstr.) (399-616) | Mgi Jnum | J:12274 |
| Mgi Id | MGI:60523 | Citation | Cox DR, et al. (1984) Assignment of the murine glandular kallikrein gene family to mouse Chromosome 7 (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet 37 (1-4):443-444 (Abstr.) (399-616) |
| abstractText | Full text of Abstract: Assignment of the murine glandular kallikrein gene family to mouse chromosome 7. D.R. Cox,1 A.J. Mason,2 B.A. Evans,2 J. Shine,2 and R.I. Richards2. 1Department of Pediatrics, University of California, San Francisco, CA and 2Department of Genetics, Australian National University, Canberra City. The murine glandular kallikrein gene family consists of 25-30 highly homologous genes which encode specific proteases involved in processing biologically active peptides such as nerve growth factor and epidermal growth factor. We have used a mouse submaxillary gland cDNA clone which codes for a member of the kallikrein family, in combination with a panel of 12 Chinese hamster-mouse somatic cell hybrids segregating mouse chromosomes, to determine the distribution of kallikrein genes in the mouse genome. Using Southern blot analyses and hybridization conditions such that the cDNA probe cross-reacted with many members of the mouse kallikrein family but did not hybridize with Chinese hamster kallikrein genes, we have found that murine kallikrein genes are linked and map to mouse chromosome 7. Each of the mouse DNA fragments hybridizing with the cDNA probe showed concordant segregation with glucose phosphate isomerase, enzyme marker for mouse chromosome 7, but discordant segregation with enzyme markers for 15 other mouse chromosomes. Karyotype analyses confirmed the assignment of the kallikrein gene family to chromosome 7. |
