| First Author | Eiche A | Year | 1984 |
| Journal | Hereditas | Volume | 101 |
| Pages | 273 (Abstr) | Mgi Jnum | J:28099 |
| Mgi Id | MGI:75731 | Citation | Eiche A, et al. (1984) An alternative to the spot test in the mouse?. Hereditas 101:273 (Abstr) |
| abstractText | Full text of Abstract: A. EICHE, U. HAGLUND AND G. ERICSSON: An alternative to the spot test in the mouse? (poster presentation). A spontaneous new mutation in the mouse was previously described (EICHE and HAGLUND 1982). This colour mutation, which occurred in an inbred subline of C57BL, is morphologically dominant but acts as a recessive lethal at late fetal stage. The carriers are grey and white. The colour pattern is distributed similarly in all animals. The heterozygous animals are as viable and fertile as nonmutant animals from the inbred subline. Revertant black spots of spontaneous origin are found in 3-5 per cent of the heterozygotes. These spots are of varying size and location. This unstable mutation has been studied for its usefulness in mutagenicity tests. Females carrying heterozygous fetuses have been treated with ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS) and procarbazine on days 8-10 of pregnancy. For all three substances, a significant increase was found in the frequency of young carrying spots. Thus, this mutation may offer a good alternative to the spot test after further evaluation. Reference: EICHE, A. and HAGLUND, U. 1982. - Heriditas 97:316-317. AB ASTRA. Toxicology Laboratories, Sodertalje, Sweden. |
