| First Author | Searle AG | Year | 1974 |
| Journal | Mouse News Lett | Volume | 50 |
| Pages | 40 | Mgi Jnum | J:13646 |
| Mgi Id | MGI:61828 | Citation | Searle AG, et al. (1974) Sex difference in chr 6 recombination frequencies. Mouse News Lett 50:40 |
| abstractText | Full text of MNL contribution: 4. Sex difference in Chr 6 recombination frequencies. When the linkage between Sig, Lc and Mi<wh> was reported in MNL 43: 29, RF' s for the two sexes were not given separately. This has now been done on more extensive data from outcrosses of Sig LC Mi<wh>/+++. Progeny were classified as follows:- Heterozygous parent: Sig Lc Mi<wh>; Male: 35; Female: 13 Heterozygous parent: +; Male: 38; Female: 22 Heterozygous parent: Sig Lc; Male: 5; Female: 2 Heterozygous parent: Mi<wh>; Male: 7; Female: 0 Heterozygous parent: Sig; Male: 14; Female: 13 Heterozygous parent: Lc Mi<wh>; Male: 12; Female: 26 Heterozygous parent: Sig Mi<wh>; Male: 0; Female: 0 Heterozygous parent: Lc; Male: 1; Female: 4 Total: Male: 112; Female: 80 The Sig-Lc RF is 0.54 in females but only 0.24 in males, while the Sig-Mi<wh> RF is 0.51 in females but 0.34 in males. Thus chiasmata seem about twice as likely to occur in the proximal half of chromosome 6 in female mice than in males. However, there is a complicating factor : there is a deficiency of Sig offspring from Sig mothers, presumably because of extra early mortality. (Searle and Beechey) |
