| First Author | Lalley PA | Year | 1984 |
| Journal | Cytogenet Cell Genet | Volume | 37 (1-4) |
| Pages | 515 (Abstr.) (399-616) | Mgi Jnum | J:4914 |
| Mgi Id | MGI:53394 | Citation | Lalley PA, et al. (1984) Mapping of mouse insulin genes (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet 37 (1-4):515 (Abstr.) (399-616) |
| abstractText | Full text of Abstract: Mapping of mouse insulin genes. P.A. Lalley1 and J.M. Chirgwin2. 1Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN, and 2Washington University, St. Louis, MO. Humans show a single insulin protein and gene while mice and rats possess two distinct insulins. To determine the chromosomal location of the mouse insulin genes we have examined Chinese hamster x mouse somatic cell hybrids segregating mouse chromosomes by restriction enzyme analysis. The data demonstrate that the mouse carries a total of three insulins located on three different chromosomes: 6, 7, and 15. The insulin gene located on chromosome 7 has been partially sequenced and these data indicate that this gene codes for insulin II protein and appears to be homologous to the human and rat II insulin genes. In man the homologous insulin gene (INS) has been assigned to chromosome llp and is syntenic with LDHA and HBB. In the mouse the homologous genes are also located on chromosome 7 indicating that a region of mouse chromosome 7 is homologous to a region of human chromosome llp. The functions of the other two insulin genes on chromosome 6 and 15 are not known. However, one should code for insulin I while the other may be a pseudo-gene. Research supported by the OHER, U.S. Department of Energy, under contractW-7405-eng-26 with Union Carbide Corporation. |
