| First Author | Lyon MF | Year | 1979 |
| Journal | Mouse News Lett | Volume | 61 |
| Pages | 37 | Mgi Jnum | J:13811 |
| Mgi Id | MGI:61990 | Citation | Lyon MF, et al. (1979) Lens opacity (Lop). Mouse News Lett 61:37 |
| abstractText | Full text of MNL contribution: New Mutant. Lens opacity (Lop). A male mouse with an inherited cataract was found in a strain homozygous for the Robertsonian Rb1Ald. Genetic tests showed that the defect was the result of a spontaneous mutation to a dominant autosomal gene, given the name lens opacity and symbol Lop. Both heterozygotes and homozygotes are viable and fertile. Cataract is detectable with the naked eye in pink-eyed animals, but only with the ophthalmoscope in black-eyed animals in both heterozygotes or homozygotes. Heterozygotes have slightly reduced and homozygotes markedly reduced size of eye. The gene is located on chr. 10 and shows 21.1 +/- 3.8% recombination with SlgbH. In backcrosses of Lop+/_SlgbH males to wild type females the offspring were SlgbH, 47: Lop, 43; SlgbHLop, 13; ++, 11. From its location Lop is not allelic with ak. Bld, bs, Cm, Dey, eb, Elo, Ie, mi, Sig, vl. Allelism has not been tested with the unlocated genes act, cac, Cad, Cat, Cts, Eo, lo, Mp, nct, or, Sey, and cataracts described by Kratochvilova (MNL 59:38). Tests to locate Lop relative to v and gr are in progress. (Lyon and Jarvis) |
