| First Author | Melvold RW | Year | 1980 |
| Journal | Mouse News Lett | Volume | 63 |
| Pages | 27 | Mgi Jnum | J:24746 |
| Mgi Id | MGI:72542 | Citation | Melvold RW (1980) A Miwh-like mutation. Mouse News Lett 63:27 |
| abstractText | Full text of MNL contribution: Research News: 2. A spontaneous mutation was found which has simultaneous effects on pigmentation and ocular development. The mutation (currently given our laboratory designation KH-179) is semidominant and is very reminiscent of Miwh--the heterozygote is "leaden" in color (on a non-agouti C57BL/6 background) and the eyes are reduced in size, frequently never opening. The homozygous mutants are entirely white and the eyes are essentially absent. However, genetic complementation tests with Miwh indicate that a separate locus in involved. Furthermore, the spotting which is characteristic of Miwh is not seen in KH-179/+ animals. Interestingly, the effect on pigmentation involves only eumelanin -- the production of phaeomelanin is unaffected and the activity of the agouti (A) gene is observable. KH-179 homozygotes which are AA or Aa have white hairs with a subterminal band of phaeomelanin and are "buffy" in appearance. Comparable bands of phaeomelanin are seen in the KH-179 heterozygote. Collaborative studies with Dr. Jan Leestma are in progress to investigate the deficiencies in the development of the eye. (Melvold) |
