| First Author | Glowinski I | Year | 1981 |
| Journal | Mouse News Lett | Volume | 64 |
| Pages | 71 | Mgi Jnum | J:13876 |
| Mgi Id | MGI:62054 | Citation | Glowinski I, et al. (1981) Liver N-acetyl transferase. Mouse News Lett 64:71 |
| abstractText | Full text of MNL contribution: Research News: Liver N-acetyl Transferase. Genetic variability was found among twenty inbred mouse strains in the N-acetylation of benzidine, an aromatic amine which requires metabolic activation to carcinogenic forms. C57BL/6J and A/J mice exhibit approximately a ten-fold difference in this activity with benzidine or with the alternative substrate aminofluorene, and were chosen for the genetic analysis of this trait. Activity distributions for F1, F2, and backcross progeny for both blood and liver reveal inheritance patterns consistent with segregation of two major codominant autosomal alleles for aminofluorene N-acetylation. This hypothesis receives further support from analysis of recombinant inbred lines developed by Dr. Muriel Nesbitt (UCSD) from A/J and C57BL/6J strains. Measurement of blood or liver aminofluorene N-acetylation showed that all lines were clearly of one or the other parental type. The high correlation (p < .001) between the activity in blood and liver allows the assignment of acetylator phenotype without sacrifice. Development of congenic lines for this trait is now in progress in our laboratory. We propose the gene symbol Nat for this variation with Natr being the common rapid acetylator allele and Nats being the slow acetylator allele found in the A/J and A/HeJ strains. (Glowinski and Weber) |
