| First Author | Peters J | Year | 1980 |
| Journal | Mouse News Lett | Volume | 63 |
| Pages | 16 | Mgi Jnum | J:13857 |
| Mgi Id | MGI:62036 | Citation | Peters J, et al. (1980) Sialidase (Neuraminidase). Mouse News Lett 63:16 |
| abstractText | Full text of MNL contribution: Biochemical variants: b) Sialidase (Neuraminidase). We have previously shown (MNL 62:52) that Aglp, alpha-glucosidase processing, is on chromosome 17, closely linked to, and possibly identical with, Apl. The variant allele Aglpa is only found in SM/J. In addition, low levels of sialidase (N-acetyl neuraminic acid hydrolase EC 3.2.1. l8), often called neuraminidase, are found in SM/J. From quantitative studies of neuraminidase levels in (C3H/HeH x SM/J)Fl and in mice resulting from the backcross (C3H/HeH x SM/J it appears that the low levels of this enzyme found in SM/J are determined by an autosomal codominant gene. The symbol Neu-1 has been proposed (Womack, per. comm). Furthermore, our data, though limited, from classifying 16 mice from this backcross, suggests that Neu-1 is on chromosome 17 since no recombinants have been found between Neu-1, Apl and Aglp. These results agree with those of Womack and Potier (MNL 61: 64). It seems probable that the several processing genes Apl, Aglp and Map-2 which are all closely linked on chromosome 17 are one and the same gene, Neu-1. (Peters and D.M. Swallow (MRC Human Biochemical Genetics Unit)). |
