| First Author | Hsieh CL | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1016 (Abstr.) | Mgi Jnum | J:12492 |
| Mgi Id | MGI:60737 | Citation | Hsieh CL, et al. (1989) The gene for GTPase activating protein (GAP) is on human Chromosome 5q and mouse Chromosome 13. Cytogenet Cell Genet 51:1016 (Abstr.) |
| abstractText | Full text of Abstract: The gene for GTPase activating protein (GAP) is on human chromosome 5q and mouse chromosome 13. (A2574) CL Hsieh, U Francke. HHMI, Beckman Center, Stanford University Medical Center, Stanford, CA GAP is a cytoplasmic protein which increases the GTPase activity of normal ras p21 protein but not of mutant oncogenic ras proteins (Trahey and McCormick, Science 238:542, 1987). It has been suggested that GAP is either an upstream regulator or a downstream target of ras p21 (Calles et al., Nature 332:548, 1988). Both bovine and human cDNA probes were provided by R. Dixon (Merck Sharp and Dohme, Research Lab., PA). The chromosome locations of the GAP gene were determined by Southern blot analyses of 13 human x rodent hybrids and 12 mouse x rodent hybrids. We have assigned this gene to human chromosome 5 and mouse chromosome 13. With two hybrids containing defined regions of human chromosome 5, we were able to localize this gene to 5q, excluding region 5q13-q15. With the BxD (from progenitor strains C57BL/6J and DBA/2J) set of recombinant inbred (RI) strains of mice, this gene was localized to the distal end of mouse chromosome 13. There were 1 recombinant among 23 strains with As-1 and no recombinant among 23 strains with Lih-1. The HGM symbol for this locus is GAP. |
