| First Author | Erickson R | Year | 1982 |
| Journal | Mouse News Lett | Volume | 66 |
| Pages | 69 | Mgi Jnum | J:13914 |
| Mgi Id | MGI:62092 | Citation | Erickson R, et al. (1982) Sts variant. Mouse News Lett 66:69 |
| abstractText | Full text of MNL contribution: Steroid Sulfatase Activity Variant. Deficiency of steroid sulfatase in man is determined by a gene(s) apparently located in the non-inactivated portion of the short arm of the X chromosome. We have found an activity variant for testicular steroid sulfatase among inbred strains of mice which is apparently not X-linked. C57BL/6J testicular extracts hydrolyze 3H-dehydroepiandrosterone sulfate twice as rapidly as do A/J extracts. The Fl were intermediate (B6A/Fl was, if anything, higher than AB6/Fl) which argues strongly against X-linkage of this trait. F2s show scattered intermediate-low values while 7 recombinant inbred lines between A/J and C57BL/6J, tested to date, appear to segregate to the parental strain values. Thus, this activity variation for steroid sulfatase appears to be determined by a single gene which is not X-linked. Of course, such an activity variant is not necessarily in the structural gene. Electrophoretic studies only disclosed a variant in the SM/J strain which may be secondary to the well-known neuraminidase variation in SM/J. (Erickson, Harper and Kramer) |
