| First Author | Bonner TI | Year | 1987 |
| Journal | Cytogenet Cell Genet | Volume | 46 |
| Pages | 584 (Abstr.) | Mgi Jnum | J:4891 |
| Mgi Id | MGI:53371 | Citation | Bonner TI, et al. (1987) The chromosomal location of the two human tackykinin genes: human substance P and neurokinin K. Cytogenet Cell Genet 46:584 (Abstr.) |
| abstractText | Full text of Abstract: 584 Abstracts of workshop presentations. The chromosomal location of the two human tackykinin genes: human substance P and neurokinin K. Bonner TI1, Young AC1, Miguel C de2, Detera-Wadleigh S2, Modi WS3, O'Bricn SJ.3 1Laboratory of Cell Biology, NIMH, Bethesda, MD. 2Clinical Neurogenetics Branch, NIMH, Bethesda, MD. 3Laboratory of Viral Carcinogenesis, NCI, Frederick, MD. The tackykinins are a family of amidated neuropeptides which share a carboxy terminal sequence Phe-X-Gly-Leu-Met-NH2 and which are found in vertebrates and invertebrates. The three known human tachykinins, substance P, neurokinin NKNA (or substance K) and neurokinin B are encoded by two genes. One gene encodes a precursor containing both substance P and neurokinin A while the other encodes a precursor containing only neurokinin NKNB. Using probes derived from the cloned human genes (Bonner et al., submitted for publication) and a panel of rodent-human somatic cell hybrids, we have assigned substance P to chromosomes 7 and neurokinin A to chromosome 12. In situ hybridization confirms the assignments and localizes the two genes to 7q21-22 and 12q13-21, respectively. Two restriction fragment polymorphisms have been identified within the sixth intron of the substance P gene: an Rsa1 polymorphism with two alleles (2.4 kb, frequency = 0.74; 2.0 kb, frequency = 0.26) and an Nco1 polymorphism (8.8 kb, frequency = 0.88; 6.7 kb, frequency = 0.12). HGM symbols: NKNA, NKNB. |
