| First Author | Miller FD | Year | 1996 |
| Journal | Semin Neurosci | Volume | 8 |
| Issue | 3 | Pages | 117-124 |
| Mgi Jnum | J:34239 | Mgi Id | MGI:81705 |
| Citation | Miller FD, et al. (1996) Analysis and manipulation of neuronal gene expression using the T alpha 1 alpha-tubulin promoter. Semin Neurosci 8(3):117-124 |
| abstractText | Analysis of the molecular genetic mechanisms underlying neuronal differentiation in mammals has been hampered by the lack, of appropriate model systems. Here, we review the evidence that the T alpha 1 alpha-tubulin gene represents such a model system. The endogenous T alpha 1 gene is expressed at highly abundant levels during the growth of developing and mature neurons. In transgenic mice, 1.1 kb of 5' flanking sequence from the T alpha 1 gene is sufficient to target gene expression to early developing neurons, and to regulate levels of expression as a function of neuronal growth. Analysis of this promoter has led to the initial elucidation of sequence elements essential for gene expression during neuronal development. Moreover, the T alpha 1 promoter provides an experimental mechanism for the manipulation and analysis of differentiating neurons in transgenic mice. |
