| First Author | Cox DR | Year | 1984 |
| Journal | Cytogenet Cell Genet | Volume | 37 (1-4) |
| Pages | 442 (Abstr.) (399-616) | Mgi Jnum | J:22910 |
| Mgi Id | MGI:71501 | Citation | Cox DR, et al. (1984) Assignment of a putative mammary oncogene (int-1) to mouse Chromosome 15 (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet 37 (1-4):442 (Abstr.) (399-616) |
| abstractText | Full text of Abstract. Most mammary carcinomas induced in C3H mice by the mouse mammary tumor virus MMTV bear a new proviral insertion within a specific region of the mouse genome, the int-1 locus. This locus, which is approximately 20 kb in length, is highly conserved in vertebrate DNA but lacks homology with known retroviral oncogenes. int-1 is transcriptionally active in mammary tumors bearing MMTV insertions at this locus, but is not transcribed in normal tissues. We have assigned int-1 to mouse chromosome 15 by using a cloned mouse DNA probe for int-1 in combination with a panel of 30 Chinese hmaster-mouse somatic cell hybrids segregating mouse chromosomes. An analysis of the segregation of int-1 with enzyme markers for each of 16 mouse chromosomes revealed concordant segregation, with one exception of int-1 and arylsulfatase A, an enzyme marker for mouse chromosome 15, but discordant segregation of int-1 and the other enzyme markers. Karyotype analyses of 12 selected hybrid clones confirmed the assignment of int-1 to mouse chromosome 15. |
