| First Author | Lyon MF | Year | 1981 |
| Journal | Mouse News Lett | Volume | 64 |
| Pages | 56 | Mgi Jnum | J:13872 |
| Mgi Id | MGI:62050 | Citation | Lyon MF, et al. (1981) Relationship of Gy and Hyp. Mouse News Lett 64:56 |
| abstractText | Full text of MNL contribution: Relationship of Gy and Hyp. In MNL 62:49 it was pointed out that Gy and Hyp both cause hypophosphataemia and defective bone growth of the rachitic type and are located close to each other on the X-chromosome. The question therefore arose whether they were allelic. Linkage tests have now been carried out using +Gy+/++Hyp females mated to Ta++/Y males, and testing the serum phosphate of all offspring. Wild-type crossovers would be detectable by normal blood phosphate, but GyHyp crossovers would probably be undetectable. To date out of 318 offspring examined a single crossover male has been detected with normal serum phosphate (5.77mg/100ml). On genetic test this animal produced several presumed XO daughters with normal serum phosphate when mated to TaO females, thus confirming his normal genotype. Thus, the recombination is 2 x 1/318 or 0.63%. It would appear that Gy and Hyp are not allelic but a closely linked gene pair. On the basis of data of others concerning the location of Gy and Crm (MNL 60:47) the map order is Ta - 25 - (Gy-0.6-Hyp) - 7 - Crm. (Lyon, Jarvis and Goyder). |
