| First Author | Fan YS | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 997 (Abstr.) | Mgi Jnum | J:4901 |
| Mgi Id | MGI:53381 | Citation | Fan YS, et al. (1989) Assignment of genes encoding three human glucose transporter/transporter-like proteins (GLUT4, GLUT5 and GLUT6) to chromosomes 17, 1 and 5 respectively. Cytogenet Cell Genet 51:997 (Abstr.) |
| abstractText | Full text of Abstract: Abstracts of workshop presentations: Assignment of genes encoding three human glucose transporter/transporter-like proteins (GLUT4, GLUT5 and GLUT6) to chromosomes 17, 1 and 5, respectively. (A2240). Y-S Fan1, RL Eddy1, MG Byers1, LL Haley1, WM Henry1, T Kayano2, TB Shows1, GI Bell2. 1Roswell Park Memorial Institute, Human Genetics Department, 666 Elm St., Buffalo, NY 14263; 2Howard Hughes Medical Institute, The University of Chicago, 5841 S. Maryland Ave., Box 391, Chicago, IL 60637 Recent studies indicate that facilitative glucose transport by mammalian cells is not the property of a unique protein but is rather an activity associated with a family of structurally related proteins. We have isolated and characterized human cDNAs encoding six different glucose transporter/ transporter-like proteins (GT). The genes for three of these have been localized to human chromosomes 1p35-p31.3 (GLUT1 Ã erythrocyte/ HepG2 GT gene) (Shows et al., Diabetes 36:546, 1987), 3q26.1-q26.3 (GLUT2 Ã liver/Beta cell GT gene) (Fukumoto et al., Proc. Natl. Acad. Sci. USA 85:5434, 1988) and 12p13.3 (GLUT3 - fetal muscle GT gene) (Kayano et al., J. Biol. Chem. 263:15245, 1988). By hybridization of cDNA probes to a panel of reduced somatic cell hybrids as well as in situ hybridization to human prometaphase chromosomes, we have now determined the chromosomal localizations of three other human GT genes: GLUT4 (insulin-responsive GT gene) - chromosome 17p13; GLUT5 (kidney GT gene) - chromosome 1p31; and GLUT6 (small intestine GT gene) - chromosome 5q34. |
