| First Author | Scalzo AA | Year | 1992 |
| Journal | FASEB J | Volume | 6 |
| Issue | 5 | Pages | A2053 (Abstr.) |
| Mgi Jnum | J:682 | Mgi Id | MGI:49217 |
| Citation | Scalzo AA, et al. (1992) The Cmv-1 resistance gene is closely linked to loci residing in the NKC region of mouse chromosome 6. FASEB J 6(5):A2053 (Abstr.) |
| abstractText | Full text of Abstract: 6468. THE Cmv-1 RESISTANCE GENE IS CLOSELY LINKED TO LOCI RESIDING IN THE NKC REGION ON MOUSE CHROMOSOME 6. A.A. Scalzo, G.R. Shellam, N.A. Fitzgerald, C.R. Wallace, P.A. Lyons, and W.M. Yokoyama. Department of Microbiology, Queen Elizabeth II Medical Center, University of Western Australia, Nedlands, 6009, W.A., Australia, and the Rosalind Russell Arthritis Research Laboratory, Department of Medicine, University of California, San Francisco, CA, 94143. In addition to H-2 genes, non H-2 genes have also been shown to play an important role in determining resistance to murine cytomegalovirus (MCMV). We have recently defined one such autosomal dominant non-H-2 gene, Cmv-1, which regulates replication of MCMV in the spleen, a critical target organ during MCMV infection. Mice with theC57BL/6 genetic background show low levels of splenic MCMV replication, and are designated Cmv-1(1), while mice with the DBA/2J and BALB/c genetic backgrounds show high levels of MCMV replication in the spleen and are designated Cmv-1h. We have also shown that the Cmv-1 gene effect is mediated by natural killer (NK) cells and that Cmv-1 maps to the distal region of chromosome 6. The purpose of this study was to resolve the relationship of Cmv-1 to other distal chromosome 6 genes. Linkage analyses using backcross constructs, (BALB/c x C57BL/6J)F1 x BALB/c and (DBA/2J x C57BL/6J)F1 x DBA/2J together with determination of the strain distribution patterns of Cmv-1 and NK1.1 in Ithe CXB and BXD sets of recombinant inbred strains has established that Cmv-1 is genetically linked to the NK cell gene complex (NKC). However, Cmv-1 is distinct from the known genes in this complex, including NK1.1, mNKR-P1, and Ly-49. The NKC encodes type II integral membrane proteins with C-type lectin domains that are selectively expressed on NK cells. Thus, the studies presented here suggest that Cmv-1 may encode an NK cell surface molecule that is specifically responsible for genetically determined resistance to MCMV and perhaps other viruses. |
