| First Author | Kocher W | Year | 1961 |
| Journal | Mouse News Lett | Volume | 24 |
| Pages | 48 | Mgi Jnum | J:179 |
| Mgi Id | MGI:48719 | Citation | Kocher W (1961) Deaf-waltzer-shaker mutants. Mouse News Lett 24:48 |
| abstractText | Full text of MNL contribution: 3) The mutants df, dn, sh-1, sh-2, pi, je, v and Va of the deaf-waltzer-shaker group have been investigated with regard to allelism, physiological interaction in double heterozygotes and effects on hearing ability during development. The genes df and v are alleles and are not at separate linked loci with a recombination fraction > 1.6%; the symbol for deaf is now vdf. vdf animals can hear for a few days before weaning. The double heterozygotes v/+; +/sh-1 and vdf/+; +/sh-1 both becone deaf at a late stage, but all the remaining double heterozygotes of the recessive genes investigated hear nornally for a t least 6 months. The degeneration of the stria vascularis is the sane in all homozygotes of the recessive genes and in Va/+, v/+; +/sh-1 and v/vdf and has already started basally by the time the animals are three days old when the outline of the stria becomes well-defined. In the middle half turn the cross-sectional area of the stria increases until the animals are about 10 days old, but later decreases. In Va/Va the degeneration of the stria is more marked from the beginning of its appearance. When the animals are about a fortnight old the degeneration of the outer hair cells in CortiÕs organ begins basally and proceeds towards the apex. There is also a parallel loss of ganglionic cells. These degenerations proceed at different speeds in the various mutants and the combinations which lead to deafness. (W. Kocher) |
