| First Author | Cattanach BM | Year | 1973 |
| Journal | Mouse News Lett | Volume | 49 |
| Pages | 30 | Mgi Jnum | J:13629 |
| Mgi Id | MGI:61811 | Citation | Cattanach BM, et al. (1973) Crossover suppression in heterozygotes for tobacco metacentric chromosomes. Mouse News Lett 49:30 |
| abstractText | Full text of MNL contribution: 6. Crossover suppression in heterozygotes for tobacco metacentric chromosomes. Crossover suppression is associated with several of the tobacco mouse metacentric chromosomes and may be related to the high rates of non-disjunction which they cause: T4Bnr: Xt was thought to lie very close to the chromosome 13 centromere since no crossing over had been detected between the locus and T4Bnr (Cattanach et al. 1971). We now find crossing over suppressed between bg, which lies close to Xt, and sa which lies 8 units distally, and that between sa and pe crossing over is enhanced. The data from repulsion backcrosses are as follows: +++,21; + sa pe. 0; bg ++, O; ++ pe, 18; bg sa+, 22; bg sa pe, 12. The sa-pe recombination is 54.79 +/- 5.83% cf. 35% expected. T4Bnr does not appear to suppress crossing over between wa-2 and vt in chromosome 11 (Cattanach and Moseley, MNL 48) but the wa-2 locus may lie considerably further away from the centromere than the linkage data indicate. The segregation of the metacentric was normal in all T4Bnr crosses. T1Bnr: T1Bnr strongly suppresses crossing over between fz and ln in chromosome 1. The data from repulsion backcrosses are as follows ++, 16; fz+, l4; + ln, 5; fz ln, 39. The fz-ln recombination is 25.68 +/- 5.08%; cf. 41% expected. Among 15 animals checked for fz none showed recombination between the locus and TlBnr. The segregation of the metacentric in most crosses was not normal. Tests for crossover suppression by all the other tobacco mouse metacentrics and also TlAld are in progress. (Cattanach and Moseley). |
