| First Author | Yan H | Year | 2025 |
| Journal | Sci Adv | Volume | 11 |
| Issue | 41 | Pages | eadx9917 |
| PubMed ID | 41061049 | Mgi Jnum | J:373122 |
| Mgi Id | MGI:8252745 | Doi | 10.1126/sciadv.adx9917 |
| Citation | Yan H, et al. (2025) Ligand-receptor interactions induce and mediate regulatory functions of BATF3(+) B cells. Sci Adv 11(41):eadx9917 |
| abstractText | B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27-IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 interaction-mediated self-targeting, these cells promoted B cell PD-L1 expression and immune evasion. Mechanistically, Il27 and Cxcl10 transcription was induced by synergizing Toll-like receptor (TLR) and CD40 signals and driven by coinduced transcription factor BATF3, which directly targeted these genes. By applying a discovery framework focusing on regulatory cells, our findings expand the recognized scope of B cell regulatory functions. |
