| First Author | Imbiakha B | Year | 2024 |
| Journal | Sci Adv | Volume | 10 |
| Issue | 1 | Pages | eadg5461 |
| PubMed ID | 38170764 | Mgi Jnum | J:370553 |
| Mgi Id | MGI:7575258 | Doi | 10.1126/sciadv.adg5461 |
| Citation | Imbiakha B, et al. (2024) Adaptive immune cells are necessary for SARS-CoV-2-induced pathology. Sci Adv 10(1):eadg5461 |
| abstractText | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic associated with morbidity and mortality in humans. Although disease severity correlates with immune dysregulation, the cellular mechanisms of inflammation and pathogenesis of COVID-19 remain relatively poorly understood. Here, we used mouse-adapted SARS-CoV-2 strain MA10 to investigate the role of adaptive immune cells in disease. We found that while infected wild-type mice lost ~10% weight by 3 to 4 days postinfection, rag(-/-) mice lacking B and T lymphocytes did not lose weight. Infected lungs at peak weight loss revealed lower pathology scores, fewer neutrophils, and lower interleukin-6 and tumor necrosis factor-alpha in rag(-/-) mice. Mice lacking alphabeta T cells also had less severe weight loss, but adoptive transfer of T and B cells into rag(-/-) mice did not significantly change the response. Collectively, these findings suggest that while adaptive immune cells are important for clearing SARS-CoV-2 infection, this comes at the expense of increased inflammation and pathology. |
