| First Author | Reis BS | Year | 2014 |
| Journal | Immunity | Volume | 41 |
| Issue | 2 | Pages | 244-56 |
| PubMed ID | 25148025 | Mgi Jnum | J:370805 |
| Mgi Id | MGI:6843662 | Doi | 10.1016/j.immuni.2014.06.017 |
| Citation | Reis BS, et al. (2014) Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity 41(2):244-56 |
| abstractText | The intestinal epithelium harbors large populations of activated and memory lymphocytes, yet these cells do not cause tissue damage in the steady state. We investigated how intestinal T cell effector differentiation is regulated upon migration to the intestinal epithelium. Using gene loss- and gain-of-function strategies, as well as reporter approaches, we showed that cooperation between the transcription factors T-bet and Runx3 resulted in suppression of conventional CD4(+) T helper functions and induction of an intraepithelial lymphocyte (IEL) program that included expression of IEL markers such as CD8alphaalpha homodimers. Interferon-gamma sensing and T-bet expression by CD4(+) T cells were both required for this program, which was distinct from conventional T helper differentiation but shared by other IEL populations, including TCRalphabeta(+)CD8alphaalpha(+) IELs. We conclude that the gut environment provides cues for IEL maturation through the interplay between T-bet and Runx3, allowing tissue-specific adaptation of mature T lymphocytes. |
