| First Author | Picou F | Year | 2012 |
| Journal | Mol Endocrinol | Volume | 26 |
| Issue | 4 | Pages | 608-18 |
| PubMed ID | 22361821 | Mgi Jnum | J:380666 |
| Mgi Id | MGI:6874877 | Doi | 10.1210/me.2011-1316 |
| Citation | Picou F, et al. (2012) A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation. Mol Endocrinol 26(4):608-18 |
| abstractText | Thyroid hormone (T(3)) can trigger a massive differentiation of cultured oligodendrocytes precursor cells (OPC) by binding the nuclear T(3) receptor alpha1 (TRalpha1). Whether this reflects a physiological function of TRalpha1 remains uncertain. Using a recently generated mouse model, in which CRE/loxP recombination is used to block its function, we show that TRalpha1 acts at two levels for the in vivo differentiation of OPC in mouse cerebellum. At the early postnatal stage, it promotes the secretion of several neurotrophic factors by acting in Purkinje neurons and astrocytes, defining an environment suitable for OPC differentiation. At later stages, TRalpha1 acts in a cell-autonomous manner to ensure the complete arrest of OPC proliferation. These data explain contradictory observations made on various models and outline the importance of T(3) signaling both for synchronizing postnatal neurodevelopment and restraining OPC proliferation in adult brain. |
