| First Author | Tumanov AV | Year | 2026 |
| Journal | Cell Rep | Volume | 45 |
| Issue | 4 | Pages | 117269 |
| PubMed ID | 42012978 | Mgi Jnum | J:389405 |
| Mgi Id | MGI:8325881 | Doi | 10.1016/j.celrep.2026.117269 |
| Citation | Tumanov AV, et al. (2026) Lymphotoxin-beta receptor controls the development of chronic pain. Cell Rep 45(4):117269 |
| abstractText | Preventing the development of chronic pain is crucial to avoiding difficult-to-manage, debilitating pain conditions. Our research identifies the lymphotoxin beta receptor (LTbetaR) as a peripheral master regulator in this process. Activation of LTbetaR induces mechanical allodynia and increases sensory neuron excitability by engaging peripheral non-neuronal cells, including macrophages and stromal cells. Conversely, local blockade of LTbetaR reduces neuronal hyperexcitability and irreversibly prevents chronic pain in a neuropathic preclinical model. These LTbetaR effects are driven by both LTbeta and LIGHT. Transcriptomic analysis reveals that LTbetaR regulates the development of chronic pain by coordinating a peripheral gene-plasticity network that involves immune-related genes and diverse cell types. Overall, LTbetaR acts as a master regulator controlling the development of pain chronicity by shaping a peripheral gene plasticity network that drives sensory neuronal sensitization. |
