Other
18 Authors
- Kirchhofer D,
- Chai Z,
- Zhang Y,
- Dong B,
- Khasawneh F,
- Valenca SDS,
- Wu C,
- Yang L,
- Shao F,
- Waters CM,
- Pandeya A,
- Shiroishi T,
- Wei Y,
- Li Z,
- Cui J,
- Qi J,
- Tao M,
- Zhang G
| First Author | Zhang Y | Year | 2025 |
| Journal | Cell Rep | Volume | 44 |
| Issue | 4 | Pages | 115479 |
| PubMed ID | 40158217 | Mgi Jnum | J:366759 |
| Mgi Id | MGI:8191186 | Doi | 10.1016/j.celrep.2025.115479 |
| Citation | Zhang Y, et al. (2025) Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure. Cell Rep 44(4):115479 |
| abstractText | The NAIP/NLRC4 inflammasome plays a pivotal role in the defense against bacterial infections, with its in vivo physiological function primarily recognized as driving inflammation in immune cells. Acute lung injury (ALI) is a leading cause of mortality in sepsis. In this study, we identify that the NAIP/NLRC4 inflammasome is highly expressed in both macrophages and pulmonary fibroblasts and that pyroptosis of these cells plays a critical role in lung injury. Mice challenged with gram-negative bacteria or flagellin developed lethal lung injury, characterized by reduced blood oxygen saturation, disrupted lung barrier function, and escalated inflammation. Flagellin-induced lung injury was protected in caspase-1 or GSDMD-deficient mice. These findings enhance our understanding of the NAIP/NLRC4 inflammasome's (patho)physiological function and highlight the significant role of inflammasome activation and pyroptosis in ALI during sepsis. |
