| First Author | Gan-Or B | Year | 2023 |
| Journal | Sci Adv | Volume | 9 |
| Issue | 39 | Pages | eade6992 |
| PubMed ID | 37774030 | Mgi Jnum | J:365894 |
| Mgi Id | MGI:7538433 | Doi | 10.1126/sciadv.ade6992 |
| Citation | Gan-Or B, et al. (2023) Cortical circuits modulate mouse social vocalizations. Sci Adv 9(39):eade6992 |
| abstractText | Vocalizations provide a means of communication with high fidelity and information rate for many species. Diencephalon and brainstem neural circuits have been shown to control mouse vocal production; however, the role of cortical circuits in this process is debatable. Using electrical and optogenetic stimulation, we identified a cortical region in the anterior cingulate cortex in which stimulation elicits ultrasonic vocalizations. Moreover, fiber photometry showed an increase in Ca(2+) dynamics preceding vocal initiation, whereas optogenetic suppression in this cortical area caused mice to emit fewer vocalizations. Last, electrophysiological recordings indicated a differential increase in neural activity in response to female social exposure dependent on vocal output. Together, these results indicate that the cortex is a key node in the neuronal circuits controlling vocal behavior in mice. |
