| First Author | Yin C | Year | 2025 |
| Journal | Neuron | Volume | 113 |
| Issue | 18 | Pages | 3048-3063.e5 |
| PubMed ID | 40602403 | Mgi Jnum | J:390077 |
| Mgi Id | MGI:8247011 | Doi | 10.1016/j.neuron.2025.06.001 |
| Citation | Yin C, et al. (2025) Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states. Neuron 113(18):3048-3063.e5 |
| abstractText | Switching between cognitive states is a natural tendency, even for trained experts. To test how cognitive states impact neural activity and behavior, we measured cortex-wide neural activity during decision-making in mice. During disengagement, neural activity was more variable across trials and could be better explained by a linear encoding model. This increase in explained variance during disengagement was associated with two changes: modestly stronger neural encoding of movements generally and an increase in task-independent movements specifically. Surprisingly, behavioral videos showed similar motion energy in both cognitive states. But while the overall amount of movements remained similar, movement alignment changed: as animals slipped into disengagement, their movements became less stereotyped. These idiosyncratic movements were a strong predictor of task performance and engagement. Taken together, our results suggest that the temporal structure of movement patterns constitutes an embodied signature of the cognitive state with a profound relationship to neural activity. |
