| First Author | Ellingford R | Year | 2026 |
| Journal | Neuron | PubMed ID | 41916281 |
| Mgi Jnum | J:384241 | Mgi Id | MGI:8323533 |
| Doi | 10.1016/j.neuron.2026.02.027 | Citation | Ellingford R, et al. (2026) Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits. Neuron |
| abstractText | Memory-based cognition relies on the integrity of cortico-hippocampal circuits, which are compromised in Alzheimer's disease (AD) as beta-amyloid (Abeta) and tau accumulate. However, the mechanisms linking this pathology to circuit dysfunction remain unclear. In mouse models, using in vivo two-photon and Neuropixels recordings, we show that Abeta-tau pathology promotes both region- and layer-specific impairments, involving reduced burst firing in superficial cortical layers and CA1 and reduced mean firing of excitatory and inhibitory neurons in deep cortical layers and CA1. Exposure to Abeta primed the susceptibility of neuronal populations to tau-induced impairment. Combined Abeta-tau reduced synaptic NMDA receptor (NMDAR) density in both mouse and human tissue, while Abeta-tau co-reduction restored NMDARs and firing patterns and improved contextual memory. NMDAR antagonism in healthy mice phenocopied regional and laminar deficits. Our findings implicate synaptic NMDAR hypofunction as a reversible mechanism linking Abeta-tau synergy to cortico-hippocampal dysfunction in AD. |
