| First Author | Tremblay KD | Year | 2025 |
| Journal | MGI Direct Data Submission | Mgi Jnum | J:374598 |
| Mgi Id | MGI:8261045 | Citation | Tremblay KD (2025) A Catalog of Novel Organogenesis Lethal KOMP Phenotypes. MGI Direct Data Submission |
| abstractText | We have analyzed a panel of mutant alleles of understudied genes that have been categorized as intermediate lethal by the Knockout Mouse Consortium (KOMP2). Thus far we have obtained and characterized 25 Knockout Mouse Project (KOMP) lines that are homozygous lethal between E9.5 and E12.5 (https://websites.umass.edu/kdtkomp/). Our analysis pipeline included determining when the embryos first exhibit a gross phenotype and analysis of the phenotype at least one day later. Both the embryo and placenta were examined using a combination of histology, immunofluorescence, and in situ hybridization. Herein we summarize the embryonic and placental phenotypes produced by each of these lethal knockout lines. We also present the endogenous expression pattern of each gene in the wild-type embryo and extraembryonic tissue. Full data sets and further information are available by contacting Dr. Kimberly D. Tremblay (kdtrembl@umass.edu). |
