| First Author | Chon U | Year | 2026 |
| Journal | Curr Biol | Volume | 36 |
| Issue | 10 | Pages | 2606-2621.e5 |
| PubMed ID | 42105756 | Mgi Jnum | J:385967 |
| Mgi Id | MGI:8344108 | Doi | 10.1016/j.cub.2026.04.037 |
| Citation | Chon U, et al. (2026) Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly. Curr Biol |
| abstractText | Precise wiring of neural circuits requires molecular strategies that ensure accurate target selection across diverse brain regions. Here, we identify inverse expression between a ligand-receptor pair, teneurin-3 (Ten3) and latrophilin-2 (Lphn2), across the developing mouse brain. Ten3 and Lphn2 exhibit inverse expression gradients along a retinotopic axis orthogonal to the ephrinA and EphA gradients, along the tonotopic axis across multiple brainstem auditory nuclei, and along the dorsomedial-ventrolateral axis in striatum and pallidum. Their inverse expression also creates discrete domains of cerebellar Purkinje cells (PCs) and cerebellar nuclei (CN). Using conditional-tag mice, we show that inverse Ten3 and Lphn2 expression patterns predict connectivity, following a "Ten3-->Ten3, Lphn2-->Lphn2" rule in all above circuits, and that Lphn2 is required in executing this rule in PCs-->CN projection. Our findings suggest a global strategy of coordinating gene expression of key wiring molecules with circuit connectivity across the developing brain. |
