| First Author | Babaeijandaghi F | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 8273 |
| PubMed ID | 38092736 | Mgi Jnum | J:343555 |
| Mgi Id | MGI:7566728 | Doi | 10.1038/s41467-023-43579-3 |
| Citation | Babaeijandaghi F, et al. (2023) DPPIV(+) fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages. Nat Commun 14(1):8273 |
| abstractText | Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or through self-renewal. While the presence of a nurturing niche is likely crucial to support the survival and function of self-renewing RMs, evidence regarding its nature is limited. Here, we identify fibro-adipogenic progenitors (FAPs) as the main source of colony-stimulating factor 1 (CSF1) in resting skeletal muscle. Using parabiosis in combination with FAP-deficient transgenic mice (Pdgfralpha(CreERT2) x DTA) or mice lacking FAP-derived CSF1 (Pdgfralpha(CreERT2) x Csf1(flox/null)), we show that local CSF1 from FAPs is required for the survival of both TIM4(-) monocyte-derived and TIM4(+) self-renewing RMs in adult skeletal muscle. The spatial distribution and number of TIM4(+) RMs coincide with those of dipeptidyl peptidase IV (DPPIV)(+) FAPs, suggesting their role as CSF1-producing niche cells for self-renewing RMs. This finding identifies opportunities to precisely manipulate the function of self-renewing RMs in situ to further unravel their role in health and disease. |
