| First Author | Sathyanarayanan A | Year | 2022 |
| Journal | Sci Adv | Volume | 8 |
| Issue | 44 | Pages | eabl9583 |
| PubMed ID | 36332016 | Mgi Jnum | J:331143 |
| Mgi Id | MGI:7386338 | Doi | 10.1126/sciadv.abl9583 |
| Citation | Sathyanarayanan A, et al. (2022) Early developmental plasticity enables the induction of an intermediate extraembryonic cell state. Sci Adv 8(44):eabl9583 |
| abstractText | Two fundamental elements of pre-implantation embryogenesis are cells' intrinsic self-organization program and their developmental plasticity, which allows embryos to compensate for alterations in cell position and number; yet, these elements are still poorly understood. To be able to decipher these features, we established culture conditions that enable the two fates of blastocysts' extraembryonic lineages-the primitive endoderm and the trophectoderm-to coexist. This plasticity emerges following the mechanisms of the first lineage segregation in the mouse embryo, and it manifests as an extended potential for extraembryonic chimerism during the pre-implantation embryogenesis. Moreover, this shared state enables robust assembly into higher-order blastocyst-like structures, thus combining both the cell fate plasticity and self-organization features of the early extraembryonic lineages. |
