| Experiment Id | GSE190891 | Name | gene expression in hippocampus from ophn1tm1Bill mouse males and controls during 24h |
| Experiment Type | transcription profiling by array | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2022-03-02 |
| description | Oligophrenin1 X-linked Intellectual disability (ID) gene is mutated in ID patients with cerebellar hypoplasia. It encodes OPHN1 protein which has been shown to interact with Rev-erb alpha, a negative regulator of the circadian clock in cells (https://doi.org/10.1038/nn.2911) In this study, we searched for gene expression differences in hippocampi from adult mouse ophn1 KO and controls during 24 hours. Three replicates were collected every 6 hours for both genotypes. Data from controls were analyzed and reported in http://dx.doi.org/10.1016/j.neuroscience.2015.08.066. Adult males were placed in dark room for 24 hours before the collection of the hippocampus every 6 hours . PCA allowed the exclusion of two time points in controls (t=0 and 12). |
