| Experiment Id | E-GEOD-9892 | Series Id | GSE9892 |
| Name | Gene expression profiling in acute murine autoimmune hepatitis | Experiment Type | transcription profiling by array |
| Study Type | WT vs. Mutant | Source | ArrayExpress |
| Curation Date | 2018-11-20 |
| description | The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-gamma. BALB/c background TGF-beta1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-beta1-/- mice, to identify gene expression pathways dependent on IFN-gamma as possible targets for rational therapy, and to test potential targets directly in vivo in mice. Keywords: Comparative analysis of gene expression in livers of WT, TGFB1 & IFN knockout mice DNA microarray analyses were applied to liver RNA from TGF-beta1-/- mice, TGF-beta1-/- /IFN-gamma-/- mice, and TGF-beta1+/+ littermate controls. 3 mice from each group were analyzed in this study. |
