| Experiment Id | E-MTAB-5849 | Name | Microarray expression analysis of Aquaporin-9 (AQP9) knockout effect in fasted C57Bl/6 mice |
| Experiment Type | transcription profiling by array | Study Type | WT vs. Mutant |
| Source | ArrayExpress | Curation Date | 2021-12-13 |
| description | Aquaporin-9 is a glycerol, urea and hydrogen peroxide channel, with highest expression in the liver. We have previously demonstrated that AQP9 is required for hepatocyte glycerol uptake and thus for gluconeogenesis from glycerol. AQP9 gene deletion in db/db mice of the C57BLKS background results in improved glycemia, while glycemia in normal mice is unaffected even during starvation, when glycerol is an important gluconeogenic substrate. To identify mechanisms that compensate the lack of glycerol uptake for gluconeogenesis, we performed a gene expression profiling and metabolomics study. |
