Experiment Id | GSE68998 | Name | Runx1- responsive genes in mdx muscles |
Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
Source | GEO | Curation Date | 2022-03-08 |
description | RNA-seq was performed to compare expression pattern of musles taken form two mice strains- mdx and mdx/Runx1f/f, which are double KO carrying a muscle specific ablation of Runx1 using a Myf5-Cre. This comparison revealed the Runx1- responsive gene set in mdx muscles. We could cross this data with prior retrieved data from previous experiments found in this GEO quary, to pinpoint Runx1 target genes in muscle regeneration. RNA was extracted from soleus muscles of 2 months old mice, n=3,4 for mdx and mdx/Runx1f/f, respectively. Differentially expressed genes were discovered using the DeSeq2 software |