| Experiment Id | GSE141181 | Name | H3K27me3 maintains the transcription program during epigenetic reprogramming in the mouse germ line [RNA-seq] |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2022-12-19 |
| description | To investigate the role of EZH2 in transcription regulation in mouse primordial germ cells, we isolated Ctrl and Ezh2 CKO male and female PGCs at E13.5. Our data demonstrates that EZH2-mediated H3K27me3 is required for regulating the expression of meiotic genes in the female germ cells. Furthermore, RNA-seq analysis shows that EZH2 is essential for transcriptional repression of retrotransposons. Expression profiles of Ctrl and Ezh2 CKO male and female mouse primordial germ cells at E13.5. |
