| Experiment Id | E-GEOD-51203 | Series Id | GSE51203 |
| Name | Expression data from mouse perigonadal white adipose tissue - various mutant conditions [exon-level analysis] | Experiment Type | transcription profiling by array |
| Study Type | WT vs. Mutant | Source | ArrayExpress |
| Curation Date | 2022-10-20 |
| description | Progerin-expressing mice (HGPS-like) demonstrated increased energy metabolism and lipodystrophy. Increased mitochondrial biogenesis was found in adipose tissue from HGPS-like mice, whereas lamin C-only mice had fewer mitochondria. Thus we analyse which molecular pathways mediated the changes in adipose tissue caused by lamin C and progerin expression and the roles of these pathways in energy metabolism and aging. 10 cDNAs samples were analysed. We compared the mean fold change of 2 to 4 biological replicates. We performed an unpaired Student's t-test to compare intensities in the different biological replicates. Genes were considered significantly regulated when the fold change was >= 1.5, and the p-value was<=0.05. |
