| Experiment Id | GSE135152 | Name | Rbfox2 is necessary for cardiovascular development |
| Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
| Source | GEO | Curation Date | 2022-12-16 |
| description | Purpose: The goal of this study is to investigate the role of Rbfox2, an RNA binding protein in cardiovascular development. Methods: RNA-Seq splicing analysis of mouse embryonic heart at embryonic day 9.5, isolated from control and genetic deletion of either one or both alleles of Rbfox2 using Nkx2-5 Cre. Rbfox2 was deleted from early cardiovascular lineage by crossing Rbfox2 floxed mice with Nkx2-5 Cre mice. Effect of Rbfox2 knock-down on alternative splicing and mRNA expression was compared between Control, heterozygous knock-out and homozygous knock-out. |
